The song "Trouble in Mind" is a widely recorded eight-bar blues standard.

It was written by Richard M. Jones (1892–1945), composer and jazz pianist. He recorded the song on February 23, 1926 with singer Bertha "Chippie" Hill and Louis Armstrong on cornet.

It has been recorded hundreds of times, including notable performances (by alphabetic order): Mose Allison; Jeff Beck (Beckology); Elkie Brooks and Humphrey Lyttelton (Trouble in Mind, 2003); Big Bill Broonzy; Johnny Cash (Unearthed Vol. 2); King Curtis (All That Blues); Barbara Dane, Bob Dylan and Mark Knopfler (recorded in 1998); Marianne Faithfull for soundtrack of the 1985 film Trouble in Mind; Aretha Franklin; Natalie Gardiner; Peter Green; Merle Haggard; Arno Hintjens; Roscoe Holcomb; John Lee Hooker; Lightnin' Hopkins; Big Walter Horton and Carey Bell; Hot Tuna (Live at Sweetwater, 1992); Janis Joplin (Janis, 1975/1993); Jerry Lee Lewis and Eric Clapton (Last Man Standing); Magnolia electric company; Jerry Lee Lewis and Ron Wood (Last Man Standing Live); Night Losers; Jim McShann, Duke Robillard and Maria Muldaur; Nina Simone (Nina Simone at Newport, 1960, and Pastel Blues, 1965); Sister Rosetta Tharpe, Big Joe Turner, Dinah Washington and Leon Russell.

The song's lyrics echo both a suicidal despair and an optimistic hope:
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"Trouble in mind, I’m blue
But I won’t be blue always
I know the sun's gonna shine in my back door someday
Oh, I got that trouble in mind, that's true
I have almost lost my mind
Oh life ain’t worth livin’

Sometimes I feel like dyin’
Tell you what I’m gonna do
I’m gonna lay my head
n some lonely railroad line

Oh, let that 2:19 train ease my trouble in mind
Meanwhile I got that trouble in mind
And I’m blue
But I won’t be blue always

Oh I know the sun's gonna shine in my back door someday
If things don't get better
I’m goin’ down to the river
I’m gonna take my old rockin' chair

Oh and if those blues overtake me
I’m gonna rock on away from here
But now I got to suffer with that trouble in mind
And I’m