"You Do Something to Me" is a song written by Cole Porter. It is notable in that it was the first number in Porter's first fully integrated-book musical Fifty Million Frenchmen (1929). In the original production, the song was performed by Genevieve Tobin and William Gaxton, performing the roles of Looloo Carroll and Peter Forbes, respectively.

The song has been revived and rerecorded many times since, notably by Howard McGillen and Susan Powell in 1991. There are two verses and two rounds of the chorus. The song has been described as "a tender prequel to "Let's Do It, Let's Fall In Love", Porter's first popular song. The song has been recorded by several artists like Mario Lanza, Frank Sinatra, Marlene Dietrich and Sinéad O'Connor. Ella Fitzgerald, the First Lady of Song, recorded this song on both her Cole Porter Songbook albums and on her Pablo classic, "Ella A Nice".
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You do something to me
Something that simply mystifies me
Tell me, why should it be,
You have the power to hypnotise me
Let me live 'neath your spell
Do do that voodoo that you do so well
For you do something to me
That nobody else could do
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